Failure of P-(di-n-propylsulfamyl)-benzoic acid (benemid) to influence p-aminosalicylic acid blood levels.

The effect of benemid (P-[DI-N-propylsulfamyl]-benzoic acid) on uric acid metabolism in one normal and one gouty subject.

Effect of benemid (p-[di-n-propylsulfamyl]-benzoic acid) on urate clearance and other discrete renal functions in gouty subjects.

Elevating Serum Penicillin Concentrations

The rapid renal clearance of penicillin has made it difficult to maintain blood levels adequate to combat resistant organisms such as enterococci and many staphylococci. Diodrast (1), p-amino-hippurate (PAH) (2), benzoic acid (3), sodium benzoate (3, 4), and carinamide (5), have been found to block renal tubular excretion of penicillin with enhancement of blood levels. Of these compounds, only ...

Synthesis and evaluation of a prodrug of 5-aminosalicylic acid for the treatment of ulcerative colitis

Objective(s): This study is aimed to design and synthesize a prodrug of 5-aminosalicylic acid and evaluate its ameliorative effect on experimental ulcerative colitis (UC).Materials and Methods: 5-Aminosalicylic acid-alanine (5-ASA-ALA) was synthesized and characterized. Its stability study was conducted in rat plasma and in the gastroint...

Acoustical Studies of Some Derivatives of 4-Amino Benzoic Acid in 1, 4-Dioxane and Dimethyl Formamide at 308.15 K

The ultrasonic velocity, density and viscosity of some Schiff bases of 4-amino benzoic acid  were measured in 1,4-dioxane and dimethylformamide at 308.15 K. Various acoustical properties such as isentropic compressibility (ks), Rao’s molar sound function (Rm), the Van der Waals constant (b), molar compressibility (W), inter molecular free len...